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Metastatic melanoma













             Multidisciplinary team management





             Immunotherapy



                  Interferon α-2b


                  Interleukin-2


                  Ipilimumab


                       Targets cytotoxic T lymphocyte

                          antigen 4 (CTLA-4)

                  Vemurafenib


                       BRAF inhibitor


                  Nivolumab/Pembrolizumab


                       Monoclonal antibodies targeting

                          programmed                   death           1       (PD1)
                          protein






             Target therapy


                  MEK, Kit inhibitor






             Chemotherapy


             Radiotherapy


             Oligo-metastastic disease


                   Surgical resection for palliation of

                     pain/ulcers
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