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Chemical burn is relatively uncommon. The
difference between thermal and chemical
burns is the insidious continuation of the
burning process with chemical burns until
the chemical is removed, neutralized or
sufficiently diluted.
The extent of tissue damage depends on:
The type of agent
Concentration +/- volume
Contact duration
Acids (pH<7) causes coagulative necrosis
and protein precipitation. This can limit the
penetration into deeper tissue.
Alkalis (pH>7) causes liquefactive necrosis by
protein denaturing and fat saponification. It
tends to cause more long term tissue
destruction by deeper tissue penetration.
Both acids and alkalis can cause damage
by tissue dehydration and exothermic
reactions. Some may cause systemic toxicity.