Page 34 - PowerPoint Presentation
P. 34

Melanoma



        Important Pathological



        Parameters








             Tumour thickness


                  Breslow thickness


                  Measured from the stratum granulosum


                     to the deepest part of the tumour


                            pT1        ≦1mm

                            pT2        1.01-2mm

                            pT3        2.01-4mm


                            pT4        >4mm

             Level of invasion


                  Clark’s level (limited use now)


                            I          Confined to epidermis


                            II         Invasion of papillary dermis

                            III        Filling of papillary dermis

                            IV         Invasion of reticular dermis


                            V          Invasion of subcutaneous fat


                    Ulceration


                        Upstages              tumour,            as       it    represents
                         aggressive behaviour



                    Neurovascular invasion


                    Microscopic satellites


                    Mitotic activity


                    BRAF V600E Gene mutation


                    PDL-1 status
   29   30   31   32   33   34   35   36   37   38   39